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Search results for "Breast cancer"

The results of a phase III study ( Study 301 ) of Eribulin mesylate ( Halaven ) versus Capecitabine ( Xeloda ) in locally advanced or metastatic breast cancer were presented at the 2012 CTRC-AACR San ...


Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of ischemic heart disease is uncertain.Res ...


Pfizer has announced that the randomized Phase 2 trial, PALOMA-1, of Palbociclib achieved its primary endpoint by demonstrating a statistically significant and clinically meaningful improvement in pro ...


The findings of a large international prospective study published in the Journal of Clinical Oncology ( JCO ) suggest for the first time that women with BRCA1 mutations should have preventive ovarian ...


Angelina Jolie's brave decision to go public with the news that she has had a double mastectomy to reduce her chances of developing breast cancer will encourage more women to think about their own ris ...


The aim of American Society of Clinical Oncology ( ASCO ) Clinical Practice Guideline is to provide evidence-based recommendations to practicing oncologists and others on systemic therapy for patients ...


Patients with progressive disease after two or more HER2-directed regimens for recurrent or metastatic breast cancer have few effective therapeutic options. TH3RESA trial has compared Trastuzumab E ...


Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, Trastuzumab, and a Platinum s ...


A retrospective analysis has compared the survival rates of women with BRCA associated breast cancer who did and did not undergo mastectomy of the contralateral breast. Participants were 390 women ...


Disease progression in patients with HER2-positive breast cancer receiving Trastuzumab ( Herceptin ) might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. A stud ...


Results from the phase III clinical trial of the investigational drug PB272 ( Neratinib ) for the extended adjuvant treatment of breast cancer ( ExteNET Trial ). The ExteNET trial is a double-blind, ...


Aromatase inhibitors effectively prevent breast cancer recurrence and development of new contralateral tumours in postmenopausal women. Researchers have assessed the efficacy and safety of the aroma ...


A new breast cancer vaccine candidate, ( GP2 ), provides further evidence of the potential of immunotherapy in preventing disease recurrence. This is especially the case for high-risk patients when it ...


LABC ( Locally advanced breast cancer ) occurs at first presentation in about one-fifth of breast cancer patients worldwide, with lower incidence in countries with established screening programmes but ...


As predicted by their DNA-damaging mechanism of action, Platinum compounds are expected to be particularly active in tumours deficient of mechanisms responsible for DNA damage repair, e.g. those witho ...