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OncoGynecology Xagena

Disease progression in patients with HER2-positive breast cancer receiving Trastuzumab ( Herceptin ) might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. A stud ...


A retrospective analysis has compared the survival rates of women with BRCA associated breast cancer who did and did not undergo mastectomy of the contralateral breast. Participants were 390 women ...


A study has determined factors influencing long term risks for acquiring or dying from invasive cervical or vaginal cancer in women previously treated for cervical intraepithelial neoplasia grade 3 ( ...


False-positive results raise suspicion for breast cancer and lead to further testing, such as additional imaging or biopsy, but do not result in a cancer diagnosis. Recent evidence from the Breast ...


Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, Trastuzumab, and a Platinum s ...


Patients with progressive disease after two or more HER2-directed regimens for recurrent or metastatic breast cancer have few effective therapeutic options. TH3RESA trial has compared Trastuzumab E ...


The aim of American Society of Clinical Oncology ( ASCO ) Clinical Practice Guideline is to provide evidence-based recommendations to practicing oncologists and others on systemic therapy for patients ...


The findings of a large international prospective study published in the Journal of Clinical Oncology ( JCO ) suggest for the first time that women with BRCA1 mutations should have preventive ovarian ...


Pfizer has announced that the randomized Phase 2 trial, PALOMA-1, of Palbociclib achieved its primary endpoint by demonstrating a statistically significant and clinically meaningful improvement in pro ...


A variety of estimates of the benefits and harms of mammographic screening for breast cancer have been published and national policies vary. The objective of a review was assess the effect of scree ...


Angelina Jolie's brave decision to go public with the news that she has had a double mastectomy to reduce her chances of developing breast cancer will encourage more women to think about their own ris ...


The results from the randomized phase II PRECEDENT trial for Vintafolide, an investigational folate small molecule drug conjugate ( SMDC ), were published in the Journal of Clinical Oncology ( JCO ), ...


Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of ischemic heart disease is uncertain.Res ...


A retrospective subgroup analysis of a phase II study ( Study 19 ) has shown the effect that an investigational drug, Olaparib, has on progression-free survival ( PFS ) compared with placebo in Platin ...


The results of a phase III study ( Study 301 ) of Eribulin mesylate ( Halaven ) versus Capecitabine ( Xeloda ) in locally advanced or metastatic breast cancer were presented at the 2012 CTRC-AACR San ...